That's an important part of Windows 11 security, reduces the chance of malicious code getting into memory. I've only just got myself a new Win 11 PC and I also disabled that to get a Logitech steering wheel to work, that was before I understood what core isolation was for. It took me about an hour or so to work out how to delete the outdated driver files that were left behind after uninstalling the old Logitech software I'd installed, before it would allow me to turn core isolation back on. Each to their own I suppose but I decided I'd rather have the security up against how often I'd likely use that wheel.