The F-4E against the Mirage 2000 in SF2 is a bit different from real life. But anything's possible, I just know that the AI sees better and I just don't feel safe flying the Phantom-E anyway, my .02$ at least in SF2. Then again Jack Locke is probably a skilled pilot as opposed to the pilot who flew the Mirage 2000.
Anyway, the best thing is if you fly a dedicated A2G bird like the E, then strike and retreat, rather than go looking for that kill. Half the time when I do strike missions in the Super I fly the route and avoid most air combat. But it's a hard call sometimes as if you bag targets on the ingress then your egress will be a little more tricky especially if you get jumped. Even then it's a matter of terrain masking, and how much you pray, and gas, how many AAMs you got, etc. But I prefer strike and retreat as opposed to balls to the wall ACM and then go to the target.