Well, my rig has been deemed to be good enough for medium settings...and an 800x600 resolution, which is probably not as pretty as some higher resolutions, but I'm used to even worse, so it's good enough for me.
First impressions:
Game runs fine, especially when you consider that Bethseda's forum is full of bug reports and that there's already a patch for FO3 in the making. I have to admit that I'm currently playing at 'very easy' difficulty, but I play games to have fun and not to be screwed over repeatedly by the AI. ... anyway, tagging small arms (and taking the 10mm pistol from the overseer's daughter) made my escape from the vault quite easy.
And when I finally left the vault I got to see this:
For a second I wanted to go back into the vault, but due to the mayhem I had caused on my way out I realized that I had no choice but to move on. Moments later I ran into some raiders...but thanks to VATS they were not much of a problem.
(I do have a pic from this encounter as well, but I'm not sure whether I should post this here)