Yes, you set up your DSR ratio in the control panel, it then opens higher resolutions in SF2 graphic options, chose these resolutions higher than your monitor native resolution and the driver will automatically use them and rescale to your native resolution.
Let's say I have a 1920x1200 monitor, when I go into the graphic tabs of SF2, the maximum resolution will be shown as 1920x1200, but if I went into the nVidia Control Panel and activated a 4x DSR ratio, the 3840x2400 resolution would also be available, if I select it, the image displayed would still be in 1920x1200 perfectly fitting my monitor but it would be downscaled from 3840x2400 automatically, giving better image quality through finer color rather than spatial resolution.